Like governments around the world, America’s 574 federally recognized tribal nations are racing to protect their citizens from the coronavirus. Impacting tribes at a rate four times higher than for the US population, the pandemic is testing the limits of tribal public health infrastructures. Simultaneously, shuttered casinos and other business enterprises are crippling tribal economies. Coupled with an inefficient federal response, resources to provide critical governmental services are being rapidly depleted, intensifying the crisis. This conversation, facilitated on May 26th, 2020 by Harvard Kennedy School’s Ash Center, features the following leaders: