In the United States, blood quantum (BQ) based enrolment criteria find their roots in settler-colonial policies to erase, assimilate, and subjugate Indigenous Peoples and individuals. As a result, Native Nations throughout the United States continue to debate such practices. Current research on Native individuals’ identities does not fully account for the impact of BQ laws. Native people’s self-identity includes their identity as an enrolled or unenrolled member of their tribe. While research has examined the formation of Indigenous identity at the community and population level, current scales and tools do not properly examine the effects of BQ based enrolment on identity at the individual level. This commentary reveals how BQ based enrolment criteria negatively impact Native Nations which implement it and calls on Native Nations and Native researchers to explore the relationship between colonial enrolment policies and the impact on identity formation and lived experiences.